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EJNMMI Physics

Table 2 Summary of the goodness-of-fit parameters and the shared population-based parameters for the evaluated lesion and kidney fit functions

From: Investigation of image-based lesion and kidney dosimetry protocols for 177Lu-PSMA-I&T therapy with and without a late SPECT/CT acquisition

Fit function

Mean CV [%] (max)

Mean SSE ± SD

Mean population parameter ± SD

MD of BED [%] ± SD (max)

P1

P2

Lesions

fmono

7.5 (15.4)

14.3 (26.5)

9.8 ± 18.3

–

–

fbi1,sγ

9.7 (30.0)

17.4 (45.7)

12.2 ± 30.7

0.799 ± 0.023 (γ)

23 ± 16 (69)

fbi1,sλ

9.4 (24.2)

20.5 (55.6)

34.3 ± 102.6

0.013 ± 0.006 h−1 (λbio)

21 ± 11 (40)

Kidneys

fmono

3.6 (10.5)

5.3 (17.4)

6.1 ± 4.3

–

9 ± 3 (15)

fbi1,sγ

3.2 (10.3)

3.9 (14.0)

3.7 ± 3.5

0.963 ± 0.004 (γ)*

–

fbi1,sλ

4.2 (9.1)

3.9 (8.0)

20.1 ± 19.3

0.021 ± 0.001 h−1 (λbio)

12 ± 12 (26)

fbi2,sA1

4.2 (10.8)

4.8 (13.2)

6.3 ± 7.9

6.220 ± 1.019 MBq (A2)

4 ± 4 (10)

  1. P1 and P2 refer to the respective two free parameters of each function. The functions for which the fit failed or the maximum CV was above 100% were neglected for model selection. The best-fit functions are highlighted by bold font. (CV coefficient of variation, SSE sum of squared errors, SD standard deviation, MD mean absolute deviation)
  2. *Parameter value according to Hardiansyah et al. [19]
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