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Table 5 Quantification errors between activity concentrations calculated with the conventional method and the SBVR method for different time per view settings for spheres, kidneys and liver in the L-KS Phantom (minus sign – overestimation)

From: Towards accurate 177Lu SPECT activity quantification and standardization using lesion-to-background voxel ratio

Organ/Sphere volume (VOI volume) [cc]

Kidney/Liver phantom Val. acquisition validation

Quantification error (%)

Time per view: 30-s

Time per view: 20-s

Time per view: 10-s

SBVR Method (CF/ SBVR)

Conv. Method (CF)

SBVR Method (CF/ SBVR)

Conv. Method (CF)

SBVR Method (CF/ SBVR)

Conv. Method (CF)

26.52 (22.7 cc)

3.40% (4.52/18.40)

− 11.31% (3.92)

4.51% (4.64/22.64)

− 13.02% (3.92)

4.92% (4.64/25.51)

− 12.53% (3.92)

11.49 (10.3 cc)

2.14% (3.82/36.04)

− 17.54% (3.19)

0.78% (3.82/36.56)

− 19.17% (3.19)

1.96% (3.82/36.50)

− 17.44% (3.19)

5.71 (6.36 cc)

− 11.88% (2.70/12.68)

− 14.43% (2.64)

− 8.31% (2.70/13.0)

− 10.77% (2.64)

− 9.24% (2.67/12.66)

− 10.26% (2.64)

Liver (~ 1600 cc)

− 1.35% (4.34/2.21)

11.86% (5.0)

− 0.30% (4.34/2.20)

13.70% (5.0)

3.20% (4.52/2.30)

15.75% (5.0)

Kidney R (~ 168 cc)

3.00% (3.80/5.0)

26.32% (5.0)

3.00% (3.80/5.1)

26.28% (5.0)

− 2.59% (3.84/5.74)

21.20% (5.0)

Kidney L (~ 170 cc)

− 5.06% (3.76/4.72)

20.98% (5.0)

− 8.98% (3.77/4.81)

17.82% (5.0)

− 6.96% (3.79/4.97)

18.92% (5.0)

  1. VOI, Volume of interest; CF, Calibration factor [cps/MBq]; and SBVR, Sphere-to-background counts/voxel ratio