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Table 3 Quantification errors between activity concentrations calculated with the conventional method and with the SBVR method for different time per view settings (minus sign – overestimation)

From: Towards accurate 177Lu SPECT activity quantification and standardization using lesion-to-background voxel ratio

Sphere volume (VOI volume) [cc]

Phantom NEMA Val. acquisition validation

Quantification error (%)

Time per view: 30-s

Time per view: 20-s

Time per view: 10-s

SBVR Method (CF/ SBVR)

Conv. Method (CF)

SBVR Method (CF/ SBVR)

Conv. Method (CF)

SBVR Method (CF/ SBVR)

Conv. Method (CF)

26.52 (22.7 cc)

0.16% (4.07/12.16)

− 3.65% (3.92)

1.72% (4.07/12.07)

− 1.78% (3.92)

4.56% (4.05/11.82)

1.39% (3.92)

11.49 (10.3 cc)

5.77% (3.15/8.90)

6.65% (3.19)

8.25% (3.13/8.71)

9.69% (3.19)

4.48% (3.19/9.32)

4.48% (3.19)

5.71 (6.36 cc)

9.34% (2.03/5.53)

30.28% (2.64)

8.84% (2.05/5.67)

29.19% (2.64)

4.41% (2.09/6.11)

24.32% (2.64)

  1. VOI, Volume of interest; CF, Calibration factor [cps/MBq]; and SBVR, Sphere-to-background counts/voxel ratio