Table 2 Percentage of variance attributable to inter- and intra-observer differences for volume, mean absorbed dose, and RECIST diameter measurements in all lesions and covariate-defined subgroups after accounting for inherent variability due to the lesions
Component of variance | All lesions (n = 140) (%) | Small lesions (n = 77) (%) | Large lesions (n = 63) (%) | Well-defined lesions (n = 84) (%) | Poorly-defined lesions (n = 56) (%) |
|---|---|---|---|---|---|
Volume | |||||
Inter-observer | 75.8 | 60.9 | 76.1 | 61.4 | 88.4 |
Intra-observer | 24.2 | 39.1 | 23.9 | 38.6 | 11.5 |
Mean absorbed dose (without RC) | |||||
Inter-observer | 61.5 | 54.5 | 76.9 | 75.0 | 53.3 |
Intra-observer | 38.5 | 45.5 | 23.1 | 25.0 | 46.7 |
Mean absorbed dose (with RC) | |||||
Inter-observer | 26.0 | 25.9 | 65.0 | 70.7 | 21.9 |
Intra-observer | 74.0 | 74.1 | 35.0 | 29.3 | 78.1 |
RECIST diameter | |||||
Inter-observer | 73.5 | 61.6 | 75.4 | 88.7 | 31.3 |
Intra-observer | 26.5 | 38.4 | 24.6 | 11.3 | 68.8 |