Fig. 5
Effect of PBIF illustrated using MIP images of Patlak MRFDG calculated using 4 × 5-min WB passes (50–70 min). A MRFDG based on a 20-min D-WB scan (50–70 min) and sPBIF; B MRFDG based on a full 70-min IDIF; C Absolute difference image; and D Relative difference image. The two MRFDG images (A) and (B) are visually identical. However, the absolute difference image (C) shows that the PBIF-based MRFDG image has systematically lower values than the IDIF-based MRFDG image. The relative difference image (D) shows almost no anatomical structures, which indicates a constant relative bias. For this patient, the use of sPBIF lead to 4% higher AUC, and consequently to 4% lower MRFDG values. The few structures, e.g. arms, seen on (D) are areas with very low MRFDG values. The input function for this patient can be found in Additional file 1: Fig. S5