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Table 1 Table of definitions and assumptions for simulation study

From: Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET

Parameter definition Cortex Spinal cord (SC) gray matter (GM) Spinal cord (SC) white matter (WM) Full spinal cord (SC) ~ 3:1 WM:GM [15]
Relative SV2A concentration, based on ex vivo SV2A concentrations [14] 1.00 0.20 0.00  
VND, Nondisplaceable Volume of Distribution 2.80 2.80 2.80 2.80
VS, Specific Volume of Distribution of SV2A 17.2 3.44 0.00 0.81
Baseline VT, Total Volume of Distribution = VND + VS 20.0a 6.24 2.80 3.83
Blocking VT (75% occupancy), Total Volume of Distribution = VND + (1 − r)*VS 7.10 3.66 2.80 3.06
  1. aApproximate mean GM VT[19]