Table 1 Table of definitions and assumptions for simulation study
From: Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET
Parameter definition | Cortex | Spinal cord (SC) gray matter (GM) | Spinal cord (SC) white matter (WM) | Full spinal cord (SC) ~ 3:1 WM:GM [15] |
|---|---|---|---|---|
Relative SV2A concentration, based on ex vivo SV2A concentrations [14] | 1.00 | 0.20 | 0.00 | |
VND, Nondisplaceable Volume of Distribution | 2.80 | 2.80 | 2.80 | 2.80 |
VS, Specific Volume of Distribution of SV2A | 17.2 | 3.44 | 0.00 | 0.81 |
Baseline VT, Total Volume of Distribution = VND + VS | 20.0a | 6.24 | 2.80 | 3.83 |
Blocking VT (75% occupancy), Total Volume of Distribution = VND + (1 − r)*VS | 7.10 | 3.66 | 2.80 | 3.06 |