166Holmium–99mTechnetium dual-isotope imaging: scatter compensation and automatic healthy-liver segmentation for 166Holmium radioembolization dosimetry

EJNMMI Physics

Table 1 Summary of the experiments

	Protocol	¹⁶⁶Ho [MBq]	^99mTc [MBq]	Scans	Reconstruction	Aim	Metric
Phantom	¹⁶⁶Ho–^99mTc dual isotope	250	25–126	8	¹⁶⁶Ho	Uniformity	Coefficient of variation
						Contrast	Hot-sphere contrast recovery
						Downscatter	¹⁶⁶Ho count density
					^99mTc	Uniformity	Coefficient of variation
						Contrast	Cold-sphere contrast recovery
						Segmentation	Recovered volume Sørensen-Dice index
	^99mTc only	0	8–240	42	^99mTc	Uniformity	Coefficient of variation
						Contrast	Cold-sphere contrast recovery
						Segmentation	Recovered volume
						Segmentation	Sørensen–Dice index
Patients	¹⁶⁶Ho–^99mTc dual isotope	224 (35)^a	50	26	¹⁶⁶Ho	Downscatter	¹⁶⁶Ho count density difference
Patients	¹⁶⁶Ho-only	224 (35)^a	0	26	¹⁶⁶Ho	Downscatter	¹⁶⁶Ho count density difference

^aMedian (and interquartile range) of administered activity among patient scout procedures