Assessment of mouse-specific pharmacokinetics in kidneys based on 131I activity measurements using micro-SPECT

EJNMMI Physics

Table 4 Overview of power function fit coefficients (c₁ and c₂) and time-integrated activity coefficient per mass of tissue (ã/M) obtained from various datasets of the left kidney FIA/g determined with GC or SPECT; and the effect of applying a correction for partial recovery to SPECT activities

Dataset [technique]	No of mice, n	No of time points	Time integration from injection until infinity						Time integration from 1.5 h until infinity
			Without RC-based correction				With RC-based correction = 1/0.85		Without RC-based correction		With RC-based correction = 1/0.85
			Function coefficients		ã_t0→∞/M (h g⁻¹)	% dev. from GC1ext ã_t0→∞/M (%)	ã_t0→∞/M (h g⁻¹)	% dev. from GC1ext ã_t0→∞/M (%)	ã_t1→∞/M (h g⁻¹)	% dev. from GC1ext ã_t1→∞/M (%)	ã_t1→∞/M (h g⁻¹)	% dev. from GC1ext ã_t1→∞/M (%)
			c₁ (g⁻¹)	c₂	ã_t0→∞/M (h g⁻¹)	% dev. from GC1ext ã_t0→∞/M (%)	ã_t0→∞/M (h g⁻¹)	% dev. from GC1ext ã_t0→∞/M (%)	ã_t1→∞/M (h g⁻¹)	% dev. from GC1ext ã_t1→∞/M (%)	ã_t1→∞/M (h g⁻¹)	% dev. from GC1ext ã_t1→∞/M (%)
GC1 [GC]	14	4	0.547	1.90	0.809	1	–	–	0.422	2	–	–
SS1 [SPECT]	14	4	0.481	1.92	0.696	− 13	0.819	2	0.357	− 14	0.421	2
GC1ext [GC]	20	6	0.551	1.92	0.803	–	–	–	0.414	–	–	–
LS1 [SPECT]	1	6	0.314	1.65	0.597	− 26	0.703	− 12	0.367	− 11	0.432	4
LS2 [SPECT]	1	6	0.326	1.66	0.619	− 23	0.728	− 9	0.380	− 8	0.447	8
LS3 [SPECT]	1	6	0.348	1.77	0.579	− 28	0.681	− 15	0.328	− 21	0.386	− 7
LS4 [SPECT]	1	6	0.314	1.74	0.542	− 32	0.639	− 20	0.315	− 24	0.371	− 10
LS5 [SPECT]	1	6	0.428	1.88	0.645	− 20	0.759	− 5	0.342	− 17	0.402	− 3