A novel semiautomated method for background activity and biological tumour volume definition to improve standardisation of 18F-FET PET imaging in glioblastoma

EJNMMI Physics

Table 1 Intra- and inter-reader coefficient of variation of the CTRL SUV_mean

CoV CTRL SUV_mean	Mirror-image [median (range)]	Guided crescent-shape [median (range)]	p value
Intra-reader variability
Overall group	0% (0–2.15%)	1.72% (0.34–9.99%)	< 0.0001
Reader #1	0% (0–0.26%)	0.99% (0.34–4.85%)	0.002
Reader #2	0% (0–2.15%)	1.69% (0.53–4.84%)	0.004
Reader #3	0% (0–1.62%)	1.25% (0.56–6.13%)	0.004
Reader #4	0% (0–1.33%)	1.10% (0.44–4.22%)	0.004
Reader #5	0% (0–0.25%)	1.73% (0.47–3.62%)	0.002
Reader #6	0% (0–1.83%)	3.94% (1.07–9.99%)	0.002
Reader #7	0% (0–0.05%)	3.10% (1.06–7.92%)	0.002
Inter-reader variability
Overall group	0.005% (0–1.05%)	2.80% (1.00–4.35%)	0.002