Fig. 13

Examples of the reference and floating lesions registered by the CNN&LM- and CNN-guided methods and their dose volume histograms from three patients. The red, blue, and green contours represent the reference lesion (MAA), the floating lesion registered by the CNN&LM-guided method (CNN&LM), and the floating lesion registered by the CNN-guided method (CNN). a, b the registered floating lesions from the CT of the DOTATATE (DOT) study; CNN&LM: score is 5, relative difference of mean dose is − 0.1%, the differences of V70 and V100 are 0.3% and − 0.1%, CNN: score is 5, relative difference of mean dose is − 0.9%, the differences of V70 and V100 are 0.2% and − 0.4%. c, d the registered floating lesions from the radiology MR (radMR); CNN&LM: score is 3, relative difference of mean dose is − 1.3%, the differences of V70 and V100 are − 0.7% and − 1.1%, CNN: score is 2, relative difference of mean dose is − 5.2%, the differences of V70 and V100 are − 1.0% and − 8.4%. e, f the registered floating lesions from radMR; CNN&LM: score is 3, relative difference of mean dose is 28.4%, the differences of V70 and V100 are 2.5% and 11.1%, CNN: score is 2, relative difference of mean dose is − 32.5%, the differences of V70 and V100 are − 11.1% and − 26.5%