Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy

EJNMMI Physics

Table 1 Percent differences between converted absorbed doses and [²¹¹At]MABG [8] absorbed dose

Organ or tissue	Converted by	[¹³¹I]MIBG [8]	[²¹¹At]MABG [9]	[¹²⁵I]MBBG [10]	[⁷⁷Br]MBBG [10]
Heart	_HL	− 19	21	− 11	3
Heart	_HL+ _RAP	10	− 7	− 5	− 5
Liver	_HL	− 21	4	− 29	− 30
Liver	_HL+ _RAP	10	− 10	1	1
Kidney	_HL	− 29	− 14	− 53	− 53
Kidney	_HL+ _RAP	10	− 9	1	− 1
Intestine	_HL	− 6	19	− 20	− 22
Intestine	_HL+ _RAP	3	− 16	− 9	− 8
Blood	_HL	− 36	13	2	5
Blood	_HL+ _RAP	12	− 2	2	− 2
Stomach	_HL	− 4	69	20	65
Stomach	_HL+ _RAP	− 1	− 1	0	0
Adrenals	_HL	− 57	− 16	− 51	− 65
Adrenals	_HL+ _RAP	10	− 8	− 2	− 2
Tumor	_HL	− 17	797	569	694
Tumor	_HL+ _RAP	− 1	0	− 1	− 1
Average	_HL	− 23	112	53	74
Average	_HL+ _RAP	7	− 7	− 2	− 2