Fig. 6

Sample of a RAP dose conversion using an optimal timing behavior map for a single biodistribution measurement (%ID/g) on ²¹¹At-labeled target compounds. First, a plotted values converted to logarithms of [¹³¹I]MIBG [8] corrected by the physical half-life of ¹³¹I, i.e., a biological component, and fitted by the linear function (the dashed line). Second, b draws the behavior map of an optimal timing (solid line) on a target compound with a physical HL of 7.2 h and a reference with a 6.9 h HL of biological clearance, T_bA2, which was derived from the fitting curve on panel (a). The dashed and dotted lines represent optimal timing in the cases of 0.95 and 1.05, and 0.9 and 1.1 times converted absorbed doses, respectively. Finally, c converted absorbed doses of [¹³¹I]MIBG [8], “with HL,” “with HL + RAP,” and a true target absorbed dose of [²¹¹At]MABG [8]