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EJNMMI Physics
Fig. 4 | EJNMMI Physics

Fig. 4

From: Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy

Fig. 4

Behavior maps of optimal timing (solid line) on radiolabeled target compounds with a physical HL of 10 d. TpA1 and TbA1 are the physical HL and HL of the biological clearance of a target, respectively. TbA2 is the half-life of the biological clearance of a reference. Behavior maps of TbA2 in these cases of 25, 50, 100, and 200 h are presented in the panels of (a), (b), (c), and (d), respectively. The dashed and dotted lines represent optimal timing in the cases of 0.95 and 1.05, and 0.9 and 1.1 times converted absorbed doses, respectively

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