Skip to main content

Table 1 Nephroprotection protocols in PRRT and selection criteria

From: Practical kidney dosimetry in peptide receptor radionuclide therapy using [177Lu]Lu-DOTATOC and [177Lu]Lu-DOTATATE with focus on uncertainty estimates

Protocol Criteria Infusion of Vamin-18
(before June 1st 2016)
Infusion of arginine/lysine mixture
(after June 1st 2016)
Aa Pre-therapeutical standard GFR ≥ 50 ml/min/1.73m2 1 l solution over 4 h starting ½ hour pre-treatment 1 l solution and 1 l saline over 4 h starting ½ hour pre-treatment
B Pre-therapeutical standard GFR of 40–49 ml/min/1.73m2, previous PRRT or multiple risk factors (e.g. nephrotoxic chemotherapy, longstanding diabetes or hypertension) 3 l solution over 12 h starting ½ hour pre-treatment 2 l solution and 1 l saline infused over 12 h starting 1 h pre-treatment. Additionally ½ l solution infused over 2 h starting 24 h post-treatment
C Pre-therapeutical standard GFR of 30–39 ml/min/1.73m2 4 l solution over about 24 h starting ½ hour pre-treatment (150–170 ml/h) 3 l solution and 1–2 l saline infused over 24–36 h starting 1 h pre-treatment. Additionally ½ l solution infused over 2 h starting 48 h post-treatment
  1. aInfusion of the arginine/lysine mixture in Protocol A corresponds to the EANM guidelines recommendations [3]