EJNMMI Physics

Table 3 SUV_max ratio and ΔHU comparisons for various groups of lesions

From: Data-driven gated PET/CT: implications for lesion segmentation and quantitation

	PET/ACT		DDG-PET		DDG-PET/CT
	\(\tilde{x }\)± σ	p	\(\tilde{x }\)± σ	p	\(\tilde{x }\)± σ	p
SUV_max ratio
Volume < 3 cc	1.31 ± 0.52	***	1.31 ± 0.24	***	1.96 ± 0.76	***
Volume > 3 cc	1.13 ± 0.26	**	1.19 ± 0.21	***	1.64 ± 0.44	***
Small versus large volume^†	‒	0.02	‒	0.02	‒	*
HU < 0	1.35 ± 0.48	***	1.27 ± 0.26	***	2.01 ± 0.69	***
HU > 0	1.04 ± 0.20	0.04	1.24 ± 0.19	***	1.44 ± 0.26	***
HU < 0 versus HU > 0^†	‒	***	‒	0.33	‒	***
Lesion ΔHU
Volume < 3 cc	322 ± 352	***	− 4.9 ± 139	0.17	562 ± 395	***
Volume > 3 cc	20.2 ± 182	*	− 25.2 ± 168	*	50.5 ± 206	**
Small versus Large Volume^†	‒	**	‒	*	‒	**
HU < 0	322 ± 321	***	− 32.1 ± 161	*	461 ± 339	***
HU > 0	5.6 ± 25.7	0.02	-0.7 ± 138	0.53	4.4 ± 25.4	0.03
HU < 0 versus HU > 0^†	‒	***	‒	***	‒	***

\(\tilde{x }\) = median, σ = standard deviation, cc = cm³, ΔHU = change in mean HU
Tests of significance (p) are relative to baseline PET/CT except those labeled with ^†
SUV_max ratio and ΔHU values are calculated relative to baseline PET/CT
baseline volume < 3 cc (n = 45), baseline volume > 3 cc (n = 46)
baseline HU < 0 (n = 53), baseline HU > 0 (n = 38)
*p < 0.01, **p < 0.001, ***p < 0.0001

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