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Table 3 Summary of model-derived TIAC for each radionuclide

From: Dosimetric impact of Ac-227 in accelerator-produced Ac-225 for alpha-emitter radiopharmaceutical therapy of patients with hematological malignancies: a pharmacokinetic modeling analysis

Tissue

Radionuclide TIAC (MBq-h/MBq 225/7Ac administered)

225Ac-Ab, 221Fr, 217At

Free 213Bi

227Ac-Ab

Total 227Th

223Ra + daughters

Adipose tissue

1.881E−01

9.406E−02

9.287E−06

3.893E−04

1.488E−04

Adrenals

1.440E−03

7.198E−04

7.106E−08

7.147E−08

2.430E−08

Lungs

2.999E−01

1.500E−01

1.480E−05

1.489E−05

5.063E−06

Brain

2.879E−02

1.440E−02

1.421E−06

1.429E−06

4.860E−07

Breasts

1.384E−02

6.919E−03

6.831E−07

6.870E−07

2.336E−07

Cortical bone surface

0.000E+00

0.000E+00

0.000E+00

7.814E−04

5.287E−04

Cortical bone

1.919E−02

9.597E−03

9.475E−07

1.333E−06

3.240E−07

Heart wall

2.399E−02

1.200E−02

1.184E−06

1.191E−06

4.050E−07

Kidneys

4.799E−02

0.000E+00

2.369E−06

5.800E−05

8.100E−07

Left colon contents

0.000E+00

0.000E+00

0.000E+00

3.792E−06

1.198E−06

Left colon wall

2.126E−02

1.063E−02

1.050E−06

9.123E−06

2.719E−06

Liver

8.255E+00

2.064E+00

5.709E−04

3.393E−04

4.050E−06

Muscle

2.519E−01

1.260E−01

1.244E−05

1.251E−05

4.253E−06

Ovaries

4.799E−04

2.399E−04

2.369E−08

7.925E−07

8.100E−09

Pancreas

1.440E−02

7.198E−03

7.106E−07

7.147E−07

2.430E−07

RM

8.396E+01

8.185E+00

5.902E−03

2.368E−03

1.620E−06

Right colon contents

0.000E+00

0.000E+00

0.000E+00

5.807E−06

1.834E−06

Right colon wall

2.126E−02

1.063E−02

1.050E−06

7.107E−06

2.082E−06

Rectosigmoid colon contents

0.000E+00

0.000E+00

0.000E+00

5.916E−06

1.869E−06

Rectosigmoid colon wall

1.026E−02

5.132E−03

5.067E−07

6.732E−06

2.048E−06

Spleen

6.153E+00

4.471E−01

4.263E−04

3.367E−04

5.670E−07

Trabecular bone surface

0.000E+00

0.000E+00

0.000E+00

7.688E−04

6.575E−04

Trabecular bone

2.879E−02

1.440E−02

1.421E−06

5.775E−06

4.860E−07

Thymus

5.535E−04

2.768E−04

2.732E−08

2.748E−08

9.343E−09

Thyroid

1.440E−03

7.198E−04

7.106E−08

7.147E−08

2.430E−08

Urinary bladder content

0.000E+00

0.000E+00

0.000E+00

1.669E−04

0.000E+00

Uterus

2.214E−03

1.107E−03

1.093E−07

1.099E−07

3.737E−08