Table 2 Model parameter values
Parameter | Value | References |
|---|---|---|
\(Ag_{0}\) (nmol) | 14.95 | Assuming 90% of 1 kg (1012) antigen-positie cells are in the distribution volume, \(V_{d}\) |
\(V_{d}\) (L) | 3.8 | [13] |
\(k_{ + }\) (M−1 h−1) | 0.5 | [13] |
\(k_{ - }\) (h−1) | 0.003 | [13] |
\(T_{c}\) (h) | 40 | [13] |
\(T_{i}\) (h) | 0.5 | Estimated |
\(T_{ci}\) (h) | 100 | Estimated |
\(f_{L1} ,f_{S1}\) | 0.18, 0.12 | [13] |
\(f_{L2} ,f_{S2}\) | 0.08, 0.06 | [13] |
\(V_{RMECF} ,V_{d}\) (L) | 0.22, 3.8 | [13] |
\(f_{Ac227}\) | 0.007 | Based on EOB fraction and assuming two 225Ac half-lives until time to injection |
\(f_{Ab}\) | 0.7 | Estimated |