Optimization of SPECT/CT imaging protocols for quantitative and qualitative 99mTc SPECT

EJNMMI Physics

Table 3 Effect of examined parameters on background AC_rec and N in comparison to a reference protocol^a

Parameter of variation	ΔAC_rec	p^b	ΔN	p^b
Parameter of variation	(kBq/ml)	p^b	(%)	p^b
SCF: 0.41	+ 1.7	< 0.0001	− 6.0	0.02
Iteration set: 4i/10s	− 0.1	n.s.^d	+ 22.0	< 0.0001
Iteration set: 5i/15s	− 0.1	n.s.^d	+ 35.3	< 0.0001
Iteration set: 24i/10s	− 0.2	n.s.^d	+ 68.1	< 0.0001
Acquisition: NEMA^c	+ 0.7	< 0.0001	− 4.1	n.s.^d

^aClinical standard for diagnostic imaging and reconstruction (60 projections with 20 s/projection, SCF_1.10, 2i/10s, Butterworth postfilter)
^bANOVA post hoc test
^cNEMA acquisition protocol (120 projections and 10 s/projection)
^dNot significant, tested by ANOVA
SCF scatter weighting factor, AC_rec mean reconstructed activity concentration, N noise