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Table 5 Absorbed dose coefficients (mGy/MBq) with contribution from alpha, beta and gamma radiation to the total absorbed dose, after simulated injection of 223Ra, in comparison to the modelling study of Lassmann and Nosske [20] and the clinical studies of Chittenden et al. [10] and Yoshida et al. [8]. Values of Yoshida et al. refer to total absorbed dose coefficients

From: Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer

  Present work Lassman and Nosske [20] Chittenden et al. [10] Yoshida et al. [8]
Tissue Alpha Beta and gamma Total Alpha Beta and gamma Alpha Beta and gamma Total
Adrenals 2.07 0.29 2.35 3.2 0.24    0.06
Brain 1.95 0.21 2.15 3.2 0.18    0.05
Breast 1.95 0.12 2.07 3.2 0.16    0.02
Colon 2.11 2.71 4.82 9.5 25 0 47 21.9
Endost-BS 215.87 5.25 221.11 750 11 5378 21 761
Kidneys 24.90 1.16 26.07 3.4 0.24 6 < 1 2.00
Liver 34.39 1.50 35.88 3.6 1.5 2 < 1 1.87
Lungs 1.96 0.19 2.15 3.2 0.19    0.03
Muscle 1.93 0.18 2.12 3.2 0.2    0.06
Pancreas 2.07 0.30 2.36 3.2 0.22    0.06
Red marrow 30.75 3.08 33.82 72 5.5 408 9 91.6
Skin 2.07 0.11 2.18 3.2 0.16    0.03
SI-wall 2.09 0.26 2.35 3.2 0.39 0 5 5.42
Spleen 2.28 0.20 2.49 3.2 0.19    0.04
Stomach wall 2.09 0.26 2.35 3.2 0.21    0.08
Testes 2.10 0.12 2.21 3.2 0.18    0.03
Thymus 1.95 0.19 2.13 3.2 0.17    0.02
Thyroid 2.03 0.14 2.17 3.2 0.17    0.03
UB-wall 1.94 0.23 2.17 3.3 0.41 3 < 1 1.54
  1. Endost-BS, endosteal cells; SI-wall, small intestine wall; UB-wall, urinary bladder (wall)