Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer

EJNMMI Physics

Table 5 Absorbed dose coefficients (mGy/MBq) with contribution from alpha, beta and gamma radiation to the total absorbed dose, after simulated injection of ²²³Ra, in comparison to the modelling study of Lassmann and Nosske [20] and the clinical studies of Chittenden et al. [10] and Yoshida et al. [8]. Values of Yoshida et al. refer to total absorbed dose coefficients

	Present work			Lassman and Nosske [20]		Chittenden et al. [10]		Yoshida et al. [8]
Tissue	Alpha	Beta and gamma	Total	Alpha	Beta and gamma	Alpha	Beta and gamma	Total
Adrenals	2.07	0.29	2.35	3.2	0.24			0.06
Brain	1.95	0.21	2.15	3.2	0.18			0.05
Breast	1.95	0.12	2.07	3.2	0.16			0.02
Colon	2.11	2.71	4.82	9.5	25	0	47	21.9
Endost-BS	215.87	5.25	221.11	750	11	5378	21	761
Kidneys	24.90	1.16	26.07	3.4	0.24	6	< 1	2.00
Liver	34.39	1.50	35.88	3.6	1.5	2	< 1	1.87
Lungs	1.96	0.19	2.15	3.2	0.19			0.03
Muscle	1.93	0.18	2.12	3.2	0.2			0.06
Pancreas	2.07	0.30	2.36	3.2	0.22			0.06
Red marrow	30.75	3.08	33.82	72	5.5	408	9	91.6
Skin	2.07	0.11	2.18	3.2	0.16			0.03
SI-wall	2.09	0.26	2.35	3.2	0.39	0	5	5.42
Spleen	2.28	0.20	2.49	3.2	0.19			0.04
Stomach wall	2.09	0.26	2.35	3.2	0.21			0.08
Testes	2.10	0.12	2.21	3.2	0.18			0.03
Thymus	1.95	0.19	2.13	3.2	0.17			0.02
Thyroid	2.03	0.14	2.17	3.2	0.17			0.03
UB-wall	1.94	0.23	2.17	3.3	0.41	3	< 1	1.54

Endost-BS, endosteal cells; SI-wall, small intestine wall; UB-wall, urinary bladder (wall)