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Table 5 Absorbed dose coefficients (mGy/MBq) with contribution from alpha, beta and gamma radiation to the total absorbed dose, after simulated injection of 223Ra, in comparison to the modelling study of Lassmann and Nosske [20] and the clinical studies of Chittenden et al. [10] and Yoshida et al. [8]. Values of Yoshida et al. refer to total absorbed dose coefficients

From: Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer

 

Present work

Lassman and Nosske [20]

Chittenden et al. [10]

Yoshida et al. [8]

Tissue

Alpha

Beta and gamma

Total

Alpha

Beta and gamma

Alpha

Beta and gamma

Total

Adrenals

2.07

0.29

2.35

3.2

0.24

  

0.06

Brain

1.95

0.21

2.15

3.2

0.18

  

0.05

Breast

1.95

0.12

2.07

3.2

0.16

  

0.02

Colon

2.11

2.71

4.82

9.5

25

0

47

21.9

Endost-BS

215.87

5.25

221.11

750

11

5378

21

761

Kidneys

24.90

1.16

26.07

3.4

0.24

6

< 1

2.00

Liver

34.39

1.50

35.88

3.6

1.5

2

< 1

1.87

Lungs

1.96

0.19

2.15

3.2

0.19

  

0.03

Muscle

1.93

0.18

2.12

3.2

0.2

  

0.06

Pancreas

2.07

0.30

2.36

3.2

0.22

  

0.06

Red marrow

30.75

3.08

33.82

72

5.5

408

9

91.6

Skin

2.07

0.11

2.18

3.2

0.16

  

0.03

SI-wall

2.09

0.26

2.35

3.2

0.39

0

5

5.42

Spleen

2.28

0.20

2.49

3.2

0.19

  

0.04

Stomach wall

2.09

0.26

2.35

3.2

0.21

  

0.08

Testes

2.10

0.12

2.21

3.2

0.18

  

0.03

Thymus

1.95

0.19

2.13

3.2

0.17

  

0.02

Thyroid

2.03

0.14

2.17

3.2

0.17

  

0.03

UB-wall

1.94

0.23

2.17

3.3

0.41

3

< 1

1.54

  1. Endost-BS, endosteal cells; SI-wall, small intestine wall; UB-wall, urinary bladder (wall)