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Table 2 Left ventricle end-diastole and end-systole volumes and ejection fraction of the heart-phantom pair. These values were measured with four imaging modalities and calculated with manual and automated methods

From: Innovative procedure for measuring left ventricular ejection fraction from 18F-FDG first-pass ultra-sensitive digital PET/CT images: evaluation with an anthropomorphic heart phantom

Modality Manual EDV, cm3 (m±SD) Automated EDV, cm3 (m±SD) Manual ESV, cm3 (m±SD) Automated ESV, cm3 (m±SD) Manual LVEF, % (m±SD) Automated LVEF, % (m±SD)
Reference value 110 62 43.6
MRI 107.0 ± 6.4
108.8 ± 3.2
120 59.7 ± 4.8
59.5 ± 2.4
67 44.3 ± 1.7
45.3 ± 1.0
44.7
SPECT ERNA 145.7 ± 50.2
111.8 ± 8.8
1131
120.8 ± 3.42
89.1 ± 41.2
75.3 ± 13.5
A.1.1.1.1.1.1. 601
51.8 ± 12.42
40.3 ± 12.2
32.8 ± 10.0
A.1.1.1.1.1.2. 46.91
57.1 ± 10.32
Planar ERNA 46.0 ± 2.8
45.1 ± 6.7
46.4
Native 3D PET/CT 103.9 ± 4.9
108.5 ± 4.9
89.5 ± 0.63 54.6 ± 2.6
58.4 ± 2.5
48.0 ± 03 47.5 ± 1.9
46.2 ± 1.6
46.4 ± 0.33
“Pseudo-planar” short-axis PET 43.6 ± 0.7
44.2 ± 0.1
43.6
“Pseudo-planar” horizontal long-axis PET 45.5 ± 0.7
44.6 ± 0.5
  1. For manual and semi-automated processes, the value corresponds to the average of 4 repetitions of the image treatment ± the standard deviation. Roman characters indicate results over 4 repetitions with 4 different observers (inter-observer variability) whereas italic characters indicate results over 4 repetitions with the same observer (intra-observer variability)
  2. CT computed tomography, EDV left ventricle end-diastole volume, ERNA equilibrium radionuclide angiocardiography, ESV left ventricle end-systole volume, LVEF left ventricular ejection fraction, MRI magnetic resonance imaging, PET positron emission tomography, SPECT single-photon emission tomography
  3. 1These SPECT values were calculated in a full automated fashion by using the QBS surface-based method
  4. 2These SPECT values were calculated in a semi-automated fashion by using the QBS surface-based method after manually placement of the anatomical landmarks—valves and septum—to help segmentation
  5. 3These PET/CT-derived values were calculated in a semi-automated fashion by using the QBS surface-based method after manually defining the anatomical landmarks—valves and septum—to help segmentation. Full automated QBS computation of PET images failed to identify the left ventricle volumes