Table 2 Results for the relevant obtained model parameters of model AV for all lesions and healthy regions. The p value for the ANOVA test for all four groups is also given, results < 0.01 are underlined. Values are presented as mean value plus-minus one standard deviation. Note BP_NP is n presented for healthy regions since k₃ and k₄ were zero or almost zero

K_a [min⁻¹]

0.5 ± 0.3

0.3 ± 0.3

0.0

0.5 ± 0.3

0.02

K_v [min⁻¹]

0.8 ± 0.7

0.4 ± 0.5

1.6

0.6 ± 0.7

0.23

k₂ [min⁻¹]

1.6 ± 0.7

0.6 ± 0.2

3.6

1.5 ± 0.6

0.01

k₃ [min⁻¹]

0.11 ± 0.03

0.21 ± 0.09

0.01

0.01 ± 0.01

0.12

k₄ [min⁻¹]

0.05 ± 0.04

0.04 ± 0.02

0.03

0.01 ± 0.01

0.33

K_i

0.10 ± 0.02

0.19 ± 0.09

0.08

0.01 ± 0.03

0.0002

V_T

3.7 ± 1.4

7.6 ± 1.5

4.7

0.06 ± 0.06

< 0.0001

V_ND

0.9 ± 0.4

1.2 ± 0.3

1.0

0.8 ± 0.2

< 0.0001

BP_ND

3.2 ± 1.3

5.6 ± 0.6

0.44