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Table 2 Reconstruction/quantification parameters and processing software used in this study. Quantification packages Q. Metrix, xSPECT Quant, and Broad quantification enable quantitative reconstructions in the scanner software

From: Variability in lutetium-177 SPECT quantification between different state-of-the-art SPECT/CT systems

System Discovery NM/CT 670 Pro Symbia Intevo Bold Symbia T16 system 1 Symbia T16 system 2 All (standardized)
Imaging center Leiden University Medical Center University Medical Center Utrecht Radboud University Medical Center Erasmus University Medical Center All
Reconstruction OSEMa + Evolution with PSFa correction WCGa + xSPECT with PSFa correction OSEMa + Flash 3D with PSFa correction OSEMa + Hybrid Recon V3.0.0 with PSFa correction OSEMa + Hybrid Recon V3.0.0 with PSFa correction
Quantification Q.Metrix xSPECT Quant/Broad Quantificationb Manual analysis Hermes SUV SPECT Hermes SUV SPECT
Iterations 9d 6 4 5 5
Subsets 10 8 8 16 16
Post-reconstruction filter None 5 mm (Gaussian) 4 mm (Gaussian) 5 mm (Gaussian) 5 mm (Gaussian)
Attenuation correction CT basedc CT basedc CT basedc CT basedc CT basedc
Scatter Correction DEWa (170 ± 10%) DEWa (170 ± 10%) DEWa (170 ± 10%) Monte Carlo-based Monte Carlo-based
Reconstruction voxel size 2.0 × 2.0 × 2.0 mm3 e 4.9 × 4.9 × 4.9 mm3 4.8 × 4.8 × 4.8 mm3 4.8 × 4.8 × 4.8 mm3 4.8 × 4.8 × 4.8 mm3
  1. a OSEM ordered subset expectation maximization; WCG weighted conjugate gradient, PSF point spread function, DEW double energy window
  2. b For xSPECT Quant and Broad quantification separate measurements were performed
  3. c Bilinear conversion of HU into attenuation coefficients at 208 keV
  4. d Settings were not according to vendor recommendation but to the literature [13]
  5. e Interpolation to 2.0 × 2.0 × 2.0 mm3 voxels by Q. Metrix for quantification, as recommended by the vendor