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Table 6 The LQ-model parameter α calculated for the x-ray irradiation and the 4 modeling assumptions adopted for the 177Lu-DOTATATE exposure (with α/β > 100 Gy): MIRDcell, truncated cone, and PM assuming the internalized source either in cytoplasm (PM-Cy) or Golgi (PM-G)

From: Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity

 

x-ray

MIRDcell

Truncated cone

PM-Cy

PM-G

α\( \left[\frac{1}{Gy}\right] \)

0.27 ± 0.08

0.19 ± 0.20

0.32 ± 0.38

0.47 ± 0.19

0.33 ± 0.13

R2

0.99

0.67

0.66

0.65

0.66