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Table 4 S values calculated for the 4-h uptake (cellular distance of 1 diameter) and the 6-day colony forming (from single cells to clusters of increasing size) for polygonal mesh models and localization of the internalized source in cytoplasm or Golgi

From: Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity

 

Polygonal mesh

Medium

Source

S(N ← CS)a b

S(N ← Cy)a b

S(N ← G)a b

4-h uptake

6.17E−05

6.23E−05

9.75E−05

9.43E−12

Colony day-1

5.77E−05

5.84E−05

9.35E−05

9.43E−12

Colony day-2

6.07E−05

6.13E−05

9.65E−05

 

Colony day-3

6.66E−05

6.70E−05

1.02E−04

 

Colony day-4

7.30E−05

7.33E−05

1.08E−04

 

Colony day-5

7.73E−05

7.76E−05

1.13E−04

 

Colony day-6

8.01E−05

8.03E−05

1.15E−04

 
  1. aMean monolayer S values (N ← CS, N ← Cy, N ← G), which is the sum of self and cross-dose to the nucleus in [Gy/(Bq s)]. bS(N ← CS)±1.28E-05, S(N ← Cy)±1.08E-05 and S(N ← G)±2.48E−05. The SD is given only by the variation in the self-S value contribution