Investigation of post-therapeutic image-based thyroid dosimetry using quantitative SPECT/CT, iodine biokinetics, and the MIRD’s voxel S values in Graves’ disease

EJNMMI Physics

Table 2 Relationship between therapeutic outcomes and thyroid-absorbed dose calculated from each method

	Hypothyroidism	Euthyroidism	Hyperthyroidism
Cases	32 (67%)	12 (25%)	4 (8%)
D_EANM [Gy]^a	231.4 ± 55.9 (136.3–344.6)	223.6 ± 68.5 (104.3–362.3)	241.0 ± 24.7 (214.6–267.5)
\( {\overline{D}}_{\mathrm{image}} \) [Gy]^b	137.5 ± 29.7 (85.4–200.7)	117.2 ± 39.5 (53.1–186.2)	139.3 ± 12.4 (126.0–155.9)
\( {\overline{D}}_{\mathrm{image},\mathrm{PVC}} \) [Gy]^c	224.3 ± 60.0 (119.3–348.6)	199.4 ± 67.9 (95.7–323.0)	222.1 ± 10.2 (211.6–235.8)

*Data are expressed as mean ± 1 standard deviation (SD), if appropriate, as maximum and minimum values
^aHypo- vs Eu-, p = 0.785; Eu- vs Hyper-, p = 0.379; Hypo- vs Hyper-, p = 0.645
^bHypo- vs Eu-, p = 0.063; Eu- vs Hyper-, p = 0.133; Hypo- vs Hyper-, p = 0.981
^cHypo- vs Eu-, p = 0.234; Eu- vs Hyper-, p = 0.317; Hypo- vs Hyper-, p = 0.903
(Bonferroni-corrected Wilcoxon-Mann-Whitney test)