TY - JOUR AU - Finocchiaro, Domenico AU - Gear, Jonathan I. AU - Fioroni, Federica AU - Flux, Glenn D. AU - Murray, Iain AU - Castellani, Gastone AU - Versari, Annibale AU - Iori, Mauro AU - Grassi, Elisa PY - 2020 DA - 2020/10/12 TI - Uncertainty analysis of tumour absorbed dose calculations in molecular radiotherapy JO - EJNMMI Physics SP - 63 VL - 7 IS - 1 AB - Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly ignored in clinical routine. However, it is essential for adequate interpretation of the results. Recently, the EANM published a practical guidance on uncertainty analysis for molecular radiotherapy based on the application of the law of propagation of uncertainty. In this study, we investigated the overall uncertainty on a sample of a patient following the EANM guidelines. The aim of this study was to provide an indication of the typical uncertainties that may be expected from performing dosimetry, to determine parameters that have the greatest effect on the accuracy of calculations and to consider the potential improvements that could be made if these effects were reduced. SN - 2197-7364 UR - https://doi.org/10.1186/s40658-020-00328-5 DO - 10.1186/s40658-020-00328-5 ID - Finocchiaro2020 ER -