Fig. 6

Mean accuracy (left column), sensitivity (middle column), and specificity (right column) of the hottest voxels putamen SBR for identification of the patients with neurodegenerative PS in the clinical sample with iterative OSEM reconstruction and resolution recovery (= setting with largest skewness of the SBR distribution). The top row shows the performance with Ln-transformation, the bottom row without Ln-transformation. The error bars indicate the difference between mean accuracy, sensitivity, or specificity and the 5th percentile over the 10,000 randomly sampled normal databases. The dashed line represents the performance of the z-score of the putamen SBR when all patients with non-neurodegenerative PS (n = 186) were used to estimate mean and standard deviation of normal putamen SBR for transforming SBR values into z-scores as benchmark