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EJNMMI Physics

Table 3 Absorbed dosea (Gy) to the nucleus of the central cell in a cluster for different distributions of 177Lu and 161Tb

From: Radiation doses from 161Tb and 177Lu in single tumour cells and micrometastases

 

Cell surface

Intracytoplasmic

Whole cell

Intranuclear

177Lu

7.2 (26%)

8.3 (36%)

11.0 (53%)

15.7 (68%)

161Tb

15.1 (33%)

17.9 (46%)

29.1 (67%)

47.8 (81%)

Enhancement factor 161Tb/177Lu

2.1

2.2

2.6

3.0

  1. aThe target cell is surrounded by a first neighbourhood of 6 cells and a second neighbourhood of 12 cells. The absorbed dose was computed considering a total electron energy release of 1436 MeV from the specific regions of interest from every cell of the cluster. The relative contribution of the self-dose is shown in parentheses
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