Table 2 Percentage differences in effective half-life from “original method” (combination trapezoidal/3-point mono-exponential fit)
From: Personalized radiation dosimetry for PRRT—how many scans are really required?
Comparison of estimated half-life | n | Mean % difference from “original method” | 95% confidence interval for mean % difference | 2.5–97.5 percentile interval | % VOIs with absolute % difference > 10% | |
|---|---|---|---|---|---|---|
4-point mono-exponential fit 0–∞ | Tumors | 85 | 2.1% | − 2.1 − 6.3% | − 36.0 − 40.2% | 28 |
Kidneys | 59 | 0.5% | − 1.4 − 2.3% | − 12.8 − 7.6% | 7 | |
Liver | 30 | − 2.9% | − 5.5 − 0.2% | − 17.1 − 11.4% | 5 | |
Spleen | 27 | − 0.9% | − 4.7 − 3.0% | − 20.4 − 18.7% | 5 | |
3-point (2, 3, 4) mono-exponential fit 0–∞ | Tumors | 85 | * | * | * | * |
Kidneys | 59 | * | * | * | * | |
Liver | 30 | * | * | * | * | |
Spleen | 27 | * | * | * | * | |
2-point (2, 4) mono-exponential fit 0–∞ | Tumors | 85 | 0.7% | 0.2 − 1.3% | − 3.9 − 5.4% | 1 |
Kidneys | 59 | 0.2% | 0.1 − 0.6% | − 2.1 − 1.4% | 0 | |
Liver | 30 | 0.5% | 0.2 − 1.3% | − 3.2 − 4.3% | 0 | |
Spleen | 27 | 0.1% | − 0.5 − 0.7% | − 2.9 − 3.1% | 0 | |
2-point (2, 3) mono-exponential fit 0–∞ | Tumors | 85 | − 2.7% | − 6.4 − 1.0% | − 35.5 − 30.1% | 33 |
Kidneys | 59 | − 1.7% | − 3.8 − 0.4% | − 17.0 − 5.8% | 12 | |
Liver | 30 | 0.9% | − 8.8 − 10.6% | − 49.3 − 51.1% | 14 | |
Spleen | 27 | − 1.3% | − 5.8 − 3.2% | − 23.2 − 20.7% | 9 | |
2-point (3, 4) mono-exponential fit 0–∞ | Tumors | 85 | 31.3% | 10.3 − 52.3% | − 154.3 − 216.9% | 53 |
Kidneys | 59 | 10.6% | 0.7 − 20.6% | − 62.2 − 46.3% | 29 | |
Liver | 30 | 27.3% | 0.9 − 53.7% | − 109.4 − 164.0% | 24 | |
Spleen | 27 | 7.8% | − 1.0 − 16.6% | − 35.3 − 50.9% | 17 |