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Table 3 Reconstruction and quantification parameters and processing software used in this study

From: Towards standardization of absolute SPECT/CT quantification: a multi-center and multi-vendor phantom study

System

Discovery NM/CT 670 Pro

Precedence 6

Symbia Intevo 6

Symbia T16 system 1

Symbia T16 system 2

All

Imaging center

Leiden University Medical Center

Maastricht University Medical Center

Noord West ziekenhuis Groep

Radboud University Medical Center

Erasmus University Medical Center

All

Reconstruction

OSEM* + Evolution with PSF* correction

OSEM* + Astonish with PSF* correction

Weighted Conjugate Gradient + xSPECT with PSF* correction

OSEM* + Flash 3D with PSF* correction

OSEM* + Hybrid Recon V1.2 with PSF* correction

OSEM* + Hybrid Recon V1.2 with PSF* correction

Quantification

Q.Metrix

Manual analysis

xSPECT Quant

Manual analysis

Hermes SUV SPECT

Hermes SUV SPECT

Iterations

9 [5]

3

24

6

5

5

Subsets

10

16

2

16

16

16

Post-reconstruction filter

None

None

7.5 mm (Gaussian)

8.4 mm (Gaussian)

5 mm (Gaussian)

5 mm (Gaussian)

Processing

GE Xeleris 4.0 workstation

Philips Extended Brilliance Workspace

Siemens Syngo.via

Siemens Inveon Research Workplace

Hermes Hybrid Viewer

In-house developed Python algorithm

Attenuation correction

CT-based, bilinear conversion of HU into attenuation coefficients at 140 keV

CT-based, HU segmentation using a step-like law, bilinear conversion of HU into attenuation coefficients at 140 keV

CT-based, bilinear conversion of HU into attenuation coefficients at 140 keV

CT-based, bilinear conversion of HU into attenuation coefficients at 140 keV

CT-based, Bilinear conversion of HU into attenuation coefficients at 140 keV

CT-based, bilinear conversion of HU into attenuation coefficients at 140 keV

Scatter Correction

DEW* (120 keV ± 10%)

Kernel based

DEW* (119 keV ± 7.5%)

DEW* (119 keV ± 10%)

Monte Carlo-based

Monte Carlo-based

Image voxel size

2.21 × 2.21 × 2.21 mm3†

4.7 × 4.7 × 4.7 mm3

2.54 × 2.54 × 2.54 mm3

4.8 × 4.8 × 4.8 mm3

4.8 × 4.8 × 4.8 mm3

4.8 × 4.8 × 4.8 mm3

  1. * OSEM ordered subset expectation maximization, PSF point spread function, DEW dual energy window
  2. † Initial acquisition was performed with 128 × 128 matrix size and corresponding voxel size of 4.42 × 4.42 × 4.42 mm3. For quantification purposes this was interpolated to a 256 × 256 matrix size and corresponding voxel size of 2.21 × 2.21 × 2.21 mm3, as recommended by the vendor.