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Table 3 Reconstruction and quantification parameters and processing software used in this study

From: Towards standardization of absolute SPECT/CT quantification: a multi-center and multi-vendor phantom study

System Discovery NM/CT 670 Pro Precedence 6 Symbia Intevo 6 Symbia T16 system 1 Symbia T16 system 2 All
Imaging center Leiden University Medical Center Maastricht University Medical Center Noord West ziekenhuis Groep Radboud University Medical Center Erasmus University Medical Center All
Reconstruction OSEM* + Evolution with PSF* correction OSEM* + Astonish with PSF* correction Weighted Conjugate Gradient + xSPECT with PSF* correction OSEM* + Flash 3D with PSF* correction OSEM* + Hybrid Recon V1.2 with PSF* correction OSEM* + Hybrid Recon V1.2 with PSF* correction
Quantification Q.Metrix Manual analysis xSPECT Quant Manual analysis Hermes SUV SPECT Hermes SUV SPECT
Iterations 9 [5] 3 24 6 5 5
Subsets 10 16 2 16 16 16
Post-reconstruction filter None None 7.5 mm (Gaussian) 8.4 mm (Gaussian) 5 mm (Gaussian) 5 mm (Gaussian)
Processing GE Xeleris 4.0 workstation Philips Extended Brilliance Workspace Siemens Syngo.via Siemens Inveon Research Workplace Hermes Hybrid Viewer In-house developed Python algorithm
Attenuation correction CT-based, bilinear conversion of HU into attenuation coefficients at 140 keV CT-based, HU segmentation using a step-like law, bilinear conversion of HU into attenuation coefficients at 140 keV CT-based, bilinear conversion of HU into attenuation coefficients at 140 keV CT-based, bilinear conversion of HU into attenuation coefficients at 140 keV CT-based, Bilinear conversion of HU into attenuation coefficients at 140 keV CT-based, bilinear conversion of HU into attenuation coefficients at 140 keV
Scatter Correction DEW* (120 keV ± 10%) Kernel based DEW* (119 keV ± 7.5%) DEW* (119 keV ± 10%) Monte Carlo-based Monte Carlo-based
Image voxel size 2.21 × 2.21 × 2.21 mm3† 4.7 × 4.7 × 4.7 mm3 2.54 × 2.54 × 2.54 mm3 4.8 × 4.8 × 4.8 mm3 4.8 × 4.8 × 4.8 mm3 4.8 × 4.8 × 4.8 mm3
  1. * OSEM ordered subset expectation maximization, PSF point spread function, DEW dual energy window
  2. † Initial acquisition was performed with 128 × 128 matrix size and corresponding voxel size of 4.42 × 4.42 × 4.42 mm3. For quantification purposes this was interpolated to a 256 × 256 matrix size and corresponding voxel size of 2.21 × 2.21 × 2.21 mm3, as recommended by the vendor.