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Table 1 Image error (mean ± standard deviation (minimum, maximum)) relative to CT attenuation correction of PET images reconstructed utilizing deepAC in various brain regions of 28 subjects and p values from paired t tests. p < 0.0024 is defined as the Bonferroni corrected significance level

From: A deep learning approach for 18F-FDG PET attenuation correction

Brain regions deepAC error (%) deepAC absolute error (%) p value (deepAC vs CTAC)
Frontal lobe left − 1.04 ± 2.35 (− 6.67, 3.32) 2.43 ± 1.57 (0.65, 6.67) 0.18
Frontal lobe right − 1.15 ± 2.56 (− 6.61, 4.06) 2.59 ± 1.69 (0.82, 6.62) 0.15
Temporal lobe left − 0.79 ± 1.70 (− 4.45, 2.22) 2.11 ± 0.94 (1.07, 4.67) 0.18
Temporal lobe right − 0.73 ± 1.99 (− 4.77, 2.68) 2.32 ± 0.96 (1.10, 4.88) 0.055
Parietal lobe left − 1.70 ± 2.25 (− 5.56, 2.22) 2.52 ± 1.63 (0.51, 5.56) 0.01
Parietal lobe right − 1.92 ± 2.38 (− 5.60, 2.28) 2.79 ± 1.61 (0.69, 5.60) 0.005
Occipital lobe left − 1.78 ± 1.95 (− 6.24, 1.40) 2.38 ± 1.43 (0.69, 6.26) 0.01
Occipital lobe right − 1.92 ± 2.15 (− 6.12, 2.81) 2.75 ± 1.25 (0.89, 6.12) 0.004
Cerebellum left − 0.22 ± 1.62 (− 3.86, 2.68) 1.70 ± 0.76 (0.67, 3.94) 0.154
Cerebellum right − 0.27 ± 1.78 (− 3.79, 2.83) 1.78 ± 0.85 (0.54, 3.79) 0.146
Brainstem 0.69 ± 1.79 (− 3.20, 3.81) 1.77 ± 0.88 (0.74, 3.81) 0.354
Caudate nucleus left 0.37 ± 1.71 (− 3.38, 3.69) 1.50 ± 0.85 (0.43, 3.69) 0.613
Caudate nucleus right 0.32 ± 1.64 (− 3.47, 3.21) 1.33 ± 0.86 (0.33, 3.47) 0.451
Putamen left − 0.67 ± 1.58 (− 3.80, 2.31) 1.41 ± 1.00 (0.24, 3.80) 0.115
Putamen right − 0.74 ± 1.53 (− 3.94, 2.08) 1.40 ± 1.02 (0.27, 3.94) 0.009
Thalamus left − 0.07 ± 1.59 (− 3.90, 3.05) 1.40 ± 0.88 (0.31, 3.91) 0.172
Thalamus right 0.00 ± 1.56 (− 4.04, 3.27) 1.34 ± 0.91 (0.20, 4.04) 0.283
Globus pallidus left − 0.39 ± 1.51 (− 3.71, 3.11) 1.25 ± 0.91 (0.12, 3.71) 0.056
Globus pallidus right − 0.56 ± 1.41 (− 3.83, 2.35) 1.24 ± 0.92 (0.29, 3.83) 0.013
Cingulate region left − 0.50 ± 1.68 (− 4.02, 2.70) 1.61 ± 0.95 (0.35 4.02) 0.049
Cingulate region right − 0.45 ± 1.63 (− 3.81, 2.28) 1.58 ± 0.87 (0.35, 3.81) 0.057
All regions − 0.64 ± 1.99 (− 4.18, 2.22) 1.74 ± 0.94 (0.29, 4.20)