Fig. 4
Hypothetical cDVHs illustrating key concepts in voxel-based dosimetry which may be used for outcome prediction. In panel (a) the situation of the red absorbed dose distribution may be expected to have a smaller impact on the tissue under consideration (less toxic or less tumor kill). This is also reflected in the D70 and V100 being lower for the red than that for the blue curve. Due to highly heterogeneous absorbed dose distributions, which is typical for radioembolization, two different cases with cDVHs as depicted in panel b might occur. Which of these cDVHs may be expected to have a larger effect on the tissue, is ambiguous (same D70 and V100) and might depend on the tissue type. c Depicts the hypothetical differences in equivalent uniform doses (EUD), derived from the situation in panel b, potentially resolving the ambiguity