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Table 4 Critical times (Tcrit) and dose rates (Rcrit) for HDR–90Y RNT

From: Comparison of radiobiological parameters for 90Y radionuclide therapy (RNT) and external beam radiotherapy (EBRT) in vitro

Cell lines λ(h−1) α(Gy−1) R0(Gy/h) Tav(h) Tcrit(days) Rcrit(Gy/h)
HCT116 0.0107 0.1981 0.792 20 [43] 5.883 0.1749
HT29 0.0107 0.0842 0.792 23 [44] 3.095 0.3578
SW48 0.0107 0.1511 0.792 24 [43] 5.538 0.1911
  1. λ, α, R0 and Tav are the decay constant for 90Y, the radiobiological parameter of the cell line, the initial dose rate of 90Y RNT and the average doubling time of the cell line, respectively