Table 2 Summary of the imaging protocols for the dosimetry used in the Iluminet trial (P) and each of the alternative treatment planning strategies tested in the current analysis (A–I) (for further details, see the main text)

Method P (as per clinical trial protocol)

Hybrid dosimetry in each cycle

Whole-body scintigraphy at 1, 24, 48 or 96 h and 168 h

1 SPECT at 24 h

Yes

Method A

4 cycles to all patients

Whole-body scintigraphy at 1, 24, 48 or 96 h and 168 h

1 SPECT at 24 h

No

Method B

Planar-based dosimetry 1st cycle only

Whole-body scintigraphy at 1, 24, 48 or 96 h and 168 h, 1st cycle only

None

Yes

Method C

Planar-based dosimetry in each cycle

Whole-body scintigraphy at 1, 24, 48 or 96 h and 168 h

None

Yes

Method D

Hybrid dosimetry 1st cycle only

Whole-body scintigraphy at 1, 24, 48 or 96 h and 168 h, 1st cycle only

1 SPECT at 24 h, 1st cycle only

Yes

Method E

Hybrid dosimetry 1st cycle + 1 SPECT/cycle thereafter

Whole-body scintigraphy at 1, 24, 48 or 96 h and 168 h, 1st cycle only

1 SPECT at 24 h

Yes

Method F

1 SPECT/cycle, identical effective halftime (51.6 h) assumed

None

1 SPECT at 24 h

Yes

Method G

1 SPECT/cycle at 96 h

None

1 SPECT at 96 h

Yes

Method H

1 SPECT at 96 h 1st cycle only

None

1 SPECT at 96 h, 1st cycle only

Yes

Method I

1 planar image at 96 h in each cycle

Whole-body scintigraphy at 96 h

None

Yes