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Table 1 Molecular radiotherapies and possibilities for dosimetric treatment planning identified in the report

From: Dosimetry-based treatment planning for molecular radiotherapy: a summary of the 2017 report from the Internal Dosimetry Task Force

Radiopharmaceutical Procedure Compounds used for pre-treatment imaging Post-treatment imaging or measurement methods
131I NaI Benign thyroid disease 131I NaI
124I NaI
123I NaI
Thyroid probe. Gamma cameraa or SPECT/CT.
131I NaI Differentiated thyroid cancer (DTC) with ablative intent and in the case of recurrent disease 131I NaI
124I NaI
123I NaI
Gamma camera or SPECT/CT.
Whole-body probes, blood sampling
131I mIBG Neuroblastoma in children and young adults 131I mIBG
124I mIBG
123I mIBG
Whole-body probe for bone marrow estimation.
Gamma camera or SPECT/CT
131I mIBG Neuroendocrine tumors in adults 131I mIBG
124I mIBG
123I mIBG
Gamma camera or SPECT/CT
177Lu DOTATATE Neuroendocrine tumors Radiolabelled somatostatin analogs Gamma camera or SPECT/CT
90Y somatostatin analogs Adult neuroendocrine disease Analogs, as 86Y–DOTATOC
111In-DOTATATE
Bremsstrahlung gamma camera or SPECT/CT.
PET/CT.
89SrCl2, 153Sm-EDTMP, 186Re-HEDP, and 188Re-HEDP Bone pain palliation 99mTc-MDP for 153Sm-EDTMP Gamma camera or SPECT/CT for 153Sm-EDTMP, 186Re-HEDP and 188Re-HEDP
223Ra dichloride Bone metastases from castration-resistant prostate cancer 99mTc-MDP Planar gamma camera imaging
177Lu PSMA ligands Metastatic castration-resistant prostate cancer Analog PET ligands SPECT/CT
90Y microspheres Liver metastases or primary tumors 99mTc-albumin macro aggregate Bremsstrahlung SPECT/CT.
PET/CT.
90Y-ibritumomab tiuxetan Non-Hodgkin’s lymphoma 111In-ibritumomab tiuxetan Bremsstrahlung gamma camera or SPECT/CT.
PET/CT.
90Y, 32P, and 186Re colloid, 169Er citrate Radiosynovectomy 99mTc MDP/HDP/HEDP and/or 99mTc-HIG Planar Gamma camera imaging,
# dicentric chromosomes
  1. aGamma camera indicates both planar scintigraphy imaging and SPECT/CT imaging, if not otherwise specified