Fig. 4

Visual comparison of PSMA-PET/CT and histoPET models according to ManReg and ManRegMI coregistration. The ManReg coregistration already shows a very good agreement between PSMA-PET and histoPET (R ² = 64.5%). Further PET-based MI coregistration results mainly in a slight shift of the histoPET in the dorsal direction (comparing rows 2 and 3) and provides a considerably better agreement (R ² = 80.7%). For better orientation, the blue crosshair is always located at the same anatomical position