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EJNMMI Physics
Fig. 3 | EJNMMI Physics

Fig. 3

From: Comparison of PET/CT and whole-mount histopathology sections of the human prostate: a new strategy for voxel-wise evaluation

Fig. 3

Localization of the prostate according to ManReg and ManRegMI. PSMA-PET/CTs for patient 1 (top), 2 (middle), and 3 (bottom) in axial, sagittal, and coronal views each (from left to right). The images show the CT-based delineation of the in vivo prostate (black), the coregistered ex vivo contour (blue, ManReg method), and the result of applying the PET-based MI transformation onto the latter (green, ManRegMI). The largest shift (about 7 mm) in case of patient 1 places the ex vivo contour slightly into the rectum according to the CT image. However, the MI algorithm still yields a well-justified transformation, as such a shift can be easily explained as an inevitable consequence of a misalignment between CT and PSMA-PET (see Discussion)

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