EORTC PET response criteria are more influenced by reconstruction inconsistencies than PERCIST but both benefit from the EARL harmonization program

EJNMMI Physics

Table 2 Agreement levels between the OSEM₁/OSEM₂ scenario and other scenarios involving reconstruction inconsistency for EORTC and PERCIST therapeutic evaluations

	Kappa (95%CI)
	EORTC	PERCIST
OSEM_PET1/OSEM_PET2 vs OSEM_PET1/PSF ± TOF_PET2	0.55 (0.39–0.72)	0.77 (0.63–0.90)
OSEM_PET1/OSEM_PET2 vs PSF ± TOF_PET1/OSEM_PET2	0.61 (0.45–0.77)	0.75 (0.62–0.88)
OSEM_PET1/OSEM_PET2 vs OSEM_PET1/PSF ± TOF.EQ_PET2	0.95 (0.89–1.00)	0.95 (0.89–1.00)
OSEM_PET1/OSEM_PET2 vs PSF ± TOF.EQ_PET1/OSEM_PET2	0.93 (0.86–1.00)	1.00 (1.00–1.00)
OSEM_PET1/OSEM_PET2 vs PSF ± TOF_PET1/PSF ± TOF_PET2	0.86 (0.75–0.97)	0.93 (0.85–1.00)
OSEM_PET1/OSEM_PET2 vs PSF ± TOF.EQ_PET1/PSF ± TOF.EQ_PET2	0.93 (0.85–1.00)	0.93 (0.85–1.00)