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Table 1 PET/CT acquisition and reconstruction parameters for the three participating centres

From: EORTC PET response criteria are more influenced by reconstruction inconsistencies than PERCIST but both benefit from the EARL harmonization program

Site and system   Centre 1 biograph 6 Centre 2 biograph mCT Centre 3 biograph 6
PET acquisition Duration per bed position 2 min and 40 s (BMI ≤25) or 3 min and 40 s (BMI >25) 2 min and 00 s 2 min and 30 s (≤65 kg), 3 min (65–85 kg), 3 min and 30 s (85–100 kg), 4 min and 00 s (>100 kg)
PET reconstruction Details   ≤65 kg 65–100 kg >100 kg
Reconstruction OSEM3D PSF OSEM3D PSF + TOF OSEM3D PSF PSF PSF
Iterations/subsets 4i 8s 3i 21s 2i 24s 2i 21s 4i 8s 3i 21s 3i 21s 3i 21s
Post-filter 5 mm 0 mm 4.4 mm 2 mm 3.5 mm 6 mm 5 mm 4 mm
Matrix 168 × 168 168 × 168 200 × 200 200 × 200 168 × 168 168 × 168 168 × 168 168 × 168
Pixel spacing 4.07 × 4.07 4.07 × 4.07 4.07 × 4.07 4.07 × 4.07 3.39 × 3.39 3.39 × 3.39 3.39 × 3.39 3.39 × 3.39
Slice thickness 5 mm 5 mm 2.027 mm 2.027 mm 3 mm 3 mm 3 mm 3 mm
EQ filter 0 mm 6.9 mm 0 mm 6.3 mm 0 mm 2.4 mm 3.9 mm 4.9 mm