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Table 6 Impact of ACSC corrections (combined and separate contributions) in phantom and human studies: percentage differences of the SBR measured with the Southampton method from the various reconstructions

From: [123I]FP-CIT ENC-DAT normal database: the impact of the reconstruction and quantification methods

SBR % difference
contributions of AC and SC
Southampton method
Phantom Controls
ACSC-IRNC
(impact of ACSC corrections combined)
39.4 47.7
IRAC-IRNC
(impact of AC losses alone)
15.5 16.5
ACSC-IRAC
(impact of SC losses alone)
24.3 31.8
  1. Top row: the % difference between ACSC-corrected and non-corrected data is higher for controls than for phantom data. An in-depth investigation (rows 2 and 3) reveals that this discrepancy is due to SC: in fact, while the AC lead to a similar increase compared to the NC values (~16%) for both phantom and controls, the SC has a higher impact for the human controls