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EJNMMI Physics

Table 6 Impact of ACSC corrections (combined and separate contributions) in phantom and human studies: percentage differences of the SBR measured with the Southampton method from the various reconstructions

From: [123I]FP-CIT ENC-DAT normal database: the impact of the reconstruction and quantification methods

SBR % difference

contributions of AC and SC

Southampton method

Phantom

Controls

ACSC-IRNC

(impact of ACSC corrections combined)

39.4

47.7

IRAC-IRNC

(impact of AC losses alone)

15.5

16.5

ACSC-IRAC

(impact of SC losses alone)

24.3

31.8

  1. Top row: the % difference between ACSC-corrected and non-corrected data is higher for controls than for phantom data. An in-depth investigation (rows 2 and 3) reveals that this discrepancy is due to SC: in fact, while the AC lead to a similar increase compared to the NC values (~16%) for both phantom and controls, the SC has a higher impact for the human controls
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