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Table 2 VOI size (cm3) and model preference (%) for [18F]HX4 kinetics in various tissues according to AIC, based on the 2.5 h dynamic PET data

From: Pharmacokinetic modeling of a novel hypoxia PET tracer [18F]HX4 in patients with non-small cell lung cancer

   Model
Tissue type VOI size (cm3) 1T2k 2T3k 2T4k 1T2k+VB 2T3k+VB 2T4k+VB
Fat 3.7 ± 1.1 25 12.5 50 12.5
Lung 20.1 ± 9.3 37.5 50 12.5
Muscle 4.5 ± 2.5 12.5 25 62.5
Liver 17.1 ± 9.2 25 75
Tumor 111.4 ± 64.1 100
Tumor, viable 48.0 ± 27.2 100
Tumor, high 3.0 ± 2.8 25 12.5 62.5
Tumor, mid 1.8 ± 0.8 12.5 25 37.5 25
Tumor, low 1.1 ± 0.2 75 25
  1. For clarity, values of 0% are not shown