A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin

EJNMMI Physics

Table 1 Initial findings with reconstruction settings of clinical scans

	Flash 3D	Hybrid Recon
Version	Siemens Syngo MI.SPECT application E.soft 2009a, 8.1.15.7 service pack 2	HERMES P5 GOLD 4.6A Hybrid Recon 1.1.2
Reconstruction algorithm	OSEM3D	OSEM3D, MAP_MRP and MAP_smoothing
# iterations–# subsets	6–16	4–16
Attenuation correction	CT-based	CT-based
Scatter correction	Triple energy window, SPECT-based	CT, Monte Carlo-based
Both photopeaks of ¹¹¹In reconstructed	Yes	Yes
Collimator correction	Mathematically calculated 3D cone beam modelling	Mathematically calculated 3D cone beam modelling
Post reconstruction filtering	Gaussian FWHM = 0.84 cm	Gaussian FWHM = 0.96 cm
Most obvious artefacts in the initial human images	Large low-intensity rim around kidneys	Small low-intensity rim around the kidneys, somewhat increased intensity in the vertebrae area