Fig. 1

Illustration of the segmentation technique used to divide the activity uptake into a high and a low uptake compartment. A region of interest of the whole body (a). The automated segmentation tool includes foci in the whole body starting with the highest uptake foci to the left on the x-axis (b). Moving to the right, more and more foci will be included (normalized number of uptake foci on the y-axis) until a threshold is reached (c), just before the number of foci increases and the noise is included (d). The cut-off between the high and low uptake compartments (nNUF = 0.1) is set at the threshold value illustrated in (c) nNUF normalized number of uptake foci ThI threshold index