Recent developments in time-of-flight PET

EJNMMI Physics

Table 4 Impact of TOF imaging on the different levels

PET performance	Image reconstruction	Image quality	Clinical performance
Reduced effect	Reduced impact of	Reduced image	Reduced acquisition
of randoms	small errors in	noise	time or dose
	data correction ^b
Higher NEC	Better algorithm	Higher SNR ^a	Gain in heavy
	convergence		patients
	Better convergence	Better small lesions	Improved lesion
	uniformity	quantitative accuracy	detectability
		Better overall image	More accurate
		quality ^a	quantification

^aEspecially for heavy patients
^bInconsistent normalization, absence of scatter correction, and mismatched attenuation correction (e.g., due to motion)