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Table 4 Impact of TOF imaging on the different levels

From: Recent developments in time-of-flight PET

PET performance Image reconstruction Image quality Clinical performance
Reduced effect Reduced impact of Reduced image Reduced acquisition
of randoms small errors in noise time or dose
  data correction b   
Higher NEC Better algorithm Higher SNR a Gain in heavy
  convergence   patients
  Better convergence Better small lesions Improved lesion
  uniformity quantitative accuracy detectability
   Better overall image More accurate
   quality a quantification
  1. aEspecially for heavy patients
  2. bInconsistent normalization, absence of scatter correction, and mismatched attenuation correction (e.g., due to motion)