Table 2 Acquisition parameters for all time points. A medium energy collimator and a single PHA energy window of 208 keV ± 10 % were used for all acquisitions
From: In vivo quantification of 177Lu with planar whole-body and SPECT/CT gamma camera imaging
Approx. time from injection (h) | Cohort | Acquisition | Parameters | Comments |
|---|---|---|---|---|
Morning of RNT | Both | Blank planar WB scan | 57Co sheet source; 10 cm min−1; range 0–199 cm; matrix 1024 × 256 | |
−1 | Both | Transmission planar WB scan | 57Co sheet source; 10 cm min−1; range 0–199 cm; matrix 1024 × 256 | Prior to administration of [177Lu]-DOTATATE |
0.5 | 1 | Whole-body planar emission scan | 177Lu; 20 cm min−1; matrix 1024 × 256 | Prior to voiding—100 % of administered radioactivity remaining in subject |
0.5 | 2 | SPECT/CT of the thorax and abdomen | 177Lu; 10 s/projection, 120 projections (3° radial sampling), step and shoot mode; acquisition matrix 128 × 128 | Venous blood sample taken at mid-point of scan |
~4 | Both | Whole-body planar emission | 177Lu; 20 cm min−1; matrix 1024 × 256 | |
~4 | Both | SPECT/CT over the kidneys | 177Lu; 15 s/projection, 120 projections (3° radial sampling), step and shoot mode; acquisition matrix 128 × 128 | Time per projection increased due to lower retained radioactivity |
~24 | Both | Whole-body planar emission | 177Lu; 10 cm min−1; matrix 1024 × 256 | |
~24 | Both | SPECT/CT over the kidneys | 177Lu; 20 s/projection, 120 projections (3° radial sampling), step and shoot mode; acquisition matrix 128 × 128 | Time per projection increased to reflect decreased overall retained radioactivity |
~96 or 120 | Both | Whole-body planar emission | 177Lu; 10 cm min−1; matrix 1024 × 256 | |
~96 or 120 | Both | SPECT/CT over the kidneys | 177Lu; 20 s/projection, 120 projections (3° radial sampling), step and shoot mode; acquisition matrix 128 × 128 |