Fig. 2

Summary of displacements introduced by FBF and GIR MC methods for [11C]-(+)-PHNO PET occupancy study data. In each box, the central mark denotes the median, the edges of the box are the 25th and 75th percentiles, the whiskers extend to the most extreme data points not considered to be outliers, and outliers are plotted individually using the symbol +. Subjects (S1–S8) exhibited various degrees of motion during the scans. The scans marked with grey background had visually negligible motion following assessment by an observer viewing the data in the movie mode in FSLview. For these scans, the FBF method introduced up to 5 mm displacement, whereas the displacement introduced by the GIR method was at a sub-voxel level. Plasma concentration of GSK618334 is also shown for each scan