Fig. 4

Box plots of liver noise (A), lesion SNR (B), lesion SBR (C) and lesion SUVmax comparison between PET/CT and simulated activity reductions (0%, 17%, 33%, 50% and 67%) with different values of factor β (150, 300, 450 and 600). Box plots of reconstructions with equal or improved values compared to PET/CT (red) are displayed in black. The central line of the box plot represents the median value and the square the mean value. The whiskers extent to the minimum and maximum values. Statistically significant differences (p ≤ 0.05) with PET/CT mean values determined by repeated measures ANOVA with additional Dunnett’s multiple comparisons test are indicated with asterisks