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Table 2 \({K}_{i}\) (mL/100 g/min) and CMRGlu (µmol/100 g/min) estimates obtained from Patlak graphical analysis alongside microparameters (\({K}_{1}\) [mL/g/min], \({k}_{2}\) [min−1], \({k}_{3}\) [min−1], and \({V}_{b}\) [mL/g]) from the standalone fitting routine for the healthy individuals included in this study (n = 18)

From: Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [18F]FDG PET

VOI

\({K}_{i}\)

CMRGlu

\({K}_{1}\)

\({k}_{2}\)

\({k}_{3}\)

\({V}_{b}\)

Total GM

2.58 ± 0.56

24.5 ± 3.6

0.120 ± 0.022

0.160 ± 0.057

0.051 ± 0.029

0.072 ± 0.013

Total WM

1.16 ± 0.25

11.0 ± 1.6

0.054 ± 0.011

0.132 ± 0.041

0.040 ± 0.022

0.042 ± 0.007

Frontal lobe

3.06 ± 0.67

29.0 ± 4.3

0.115 ± 0.021

0.133 ± 0.054

0.055 ± 0.035

0.065 ± 0.012

Occipital lobe

2.65 ± 0.55

25.2 ± 3.5

0.114 ± 0.022

0.146 ± 0.052

0.053 ± 0.031

0.084 ± 0.013

Parietal lobe

2.76 ± 0.66

26.2 ± 4.5

0.111 ± 0.023

0.184 ± 0.055

0.042 ± 0.023

0.089 ± 0.019

Temporal lobe

2.64 ± 0.56

25.0 ± 3.6

0.115 ± 0.020

0.162 ± 0.069

0.055 ± 0.032

0.063 ± 0.013

Insula

2.70 ± 0.62

25.6 ± 4.1

0.107 ± 0.019

0.137 ± 0.051

0.055 ± 0.033

0.065 ± 0.014

Hippocampus

1.84 ± 0.38

17.5 ± 2.5

0.125 ± 0.022

0.153 ± 0.063

0.057 ± 0.036

0.079 ± 0.016

Precuneus

2.99 ± 0.69

28.4 ± 4.7

0.134 ± 0.025

0.146 ± 0.060

0.057 ± 0.035

0.076 ± 0.015

Putamen

3.34 ± 0.70

31.7 ± 4.2

0.136 ± 0.025

0.177 ± 0.075

0.054 ± 0.034

0.097 ± 0.019

Thalamus

2.77 ± 0.63

26.2 ± 4.0

0.114 ± 0.021

0.152 ± 0.055

0.053 ± 0.031

0.071 ± 0.011

Cerebellum

2.21 ± 0.50

20.9 ± 3.3

0.150 ± 0.030

0.202 ± 0.063

0.041 ± 0.021

0.083 ± 0.016

  1. Results were obtained with the derived MDIFs and are presented as mean ± one standard deviation
  2. CMRGlu Cerebral metabolic rate of glucose; GM Grey matter; MDIF Model-derived input function; VOI Volume-of-interest; WM White matter