Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [18F]FDG PET

EJNMMI Physics

Table 1 Microparameters used to define regional TACs for six theoretical VOIs included in the simulations

Microparameters	VOI 1^a	VOI 2^b	VOI 3^c	VOI 4^d	VOI 5^a	VOI 6^d	Average (WB)^e
\({K}_{1}\)(mL/g/min)	0.105	0.123	0.096	0.088	0.069	0.062	0.090
\({k}_{2}\)(min⁻¹)	0.148	0.121	0.109	0.123	0.129	0.071	0.117
\({k}_{3}\)(min⁻¹)	0.074	0.079	0.042	0.071	0.064	0.067	0.066
\({V}_{b}\)(mL/g)	0.050^f	0.059	0.050^f	0.084	0.050^d	0.050	0.067
\({K}_{i}\)(mL/g/min)	0.035	0.049	0.027	0.032	0.023	0.030	0.033

^aBased on the work of Reivich et al. [35]
^bBased on the work of Sari et al. [9]
^cBased on the work of Zanotti-Fregonara et al. [36]
^dBased on the work of Huisman et al. [37]
^eWB TAC was obtained by using the average microparameters
^fCBV was not reported
CBV Cerebral blood volume; TACs Time-activity curve; VOI Volume-of-interest; WB Whole brain