Biodistribution and radiation dosimetry of 124I-mIBG in adult patients with neural crest tumours and extrapolation to paediatric models

EJNMMI Physics

Table 5 Measured mean (± SD) effective dose coefficient (mSv/MBq) for ¹²⁴I-mIBG in adult patients, extrapolated mean values for reference paediatric patients, and projected mean (± SD) values for ¹²³I-mIBG and ¹³¹I-mIBG in adult patients. Values within parentheses are provided by ICRP publication 53 for ¹²⁴I-mIBG and publication 80 for ¹²³I-mIBG and ¹³¹I-mIBG [15, 18]

Effective dose coefficient (mSv/MBq)
Adult patients
¹²⁴I-mIBG		¹²³I-mIBG - projected		¹³¹I-mIBG - projected
Male	Female	Male	Female	Male	Female
0.24 ± 0.03	0.26 ± 0.06	0.014 ± 0.002	0.015 ± 0.002	0.18 ± 0.04	0.19 ± 0.05
(0.24)		(0.013)		(0.14)

Paediatric reference patients
¹²⁴I-mIBG - extrapolated
15-yrs old	10-yrs old	5-yrs old	1-yr old	Newborn
0.29 (0.30)	0.44 (0.44)	0.69 (0.67)	1.21 (1.2)	2.94 (–)
0.005*	0.014*	0.036*	0.12*	0.84*